Synthesis of (3α,7β,17α)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer

Author:

Plate Ralf,van Wuijtswinkel Rob C.A.L,Jans Christan G.J.M,Groen Marinus B

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Pharmacology,Endocrinology,Molecular Biology,Biochemistry

Reference10 articles.

1. Tibolone (Livial). A new steroid for the menopause. Drug Ther Bull 1991;29:77–8.

2. Moore RA. Systematic and economic review for Livial. In: Rymer J (Ed.), Livial: A review of clinical studies. Br J Gynaecol 1999;106(3 Suppl. 19) 1.

3. An alternative synthesis of 17β-hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one (ORG OD14);Van Vliet;Recl Trav Chim Pays-Bas,1986

4. Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes;Sandker;Xenobiotica,1994

5. Inhibition of dehydroandrosterone 7α- and 7β-hydroxylation in mouse;Doostzadeh;Steroids,1998

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