Identification of Absidia orchidis steroid 11β-hydroxylation system and its application in engineering Saccharomyces cerevisiae for one-step biotransformation to produce hydrocortisone

Author:

Chen Jing,Fan Feiyu,Qu Ge,Tang Jinlei,Xi Yongyan,Bi Changhao,Sun Zhoutong,Zhang Xueli

Funder

Key Research Program of the Chinese Academy of Science

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference50 articles.

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2. The human steroid hydroxylases CYP1B1 and CYP11B2;Bureik;Biol. Chem.,2002

3. The 11 beta-hydroxylation of 16,17 alpha-epoxyprogesterone and the purification of the 11 beta-hydroxylase from Absidia coerulea IBL02;Chen;Enzym. Microb. Technol.,2007

4. The ins and outs of cytochrome P450s;Cojocaru;Biochim. Biophys. Acta,2007

5. Corinne, B. M., Isabelle, B., Dumas, B., 2018. Process for Preparing Genetically Transformed Yeasts Capable of Producing a Molecule of Interest at a High Titre. Patent US 9994888B2.

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