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Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A

  • Published:2019-07 Issue: Volume:45 Page:139-154
  • ISSN:2352-3964
  • Container-title:EBioMedicine
  • language:en
  • Short-container-title:EBioMedicine

Author:

Burgermeister ElkeORCID,Battaglin Francesca,Eladly Fagr,Wu Wen,Herweck Frank,Schulte Nadine,Betge Johannes,Härtel Nicolai,Kather Jakob N.,Weis Cleo-Aron,Gaiser Timo,Marx Alexander,Weiss Christel,Hofheinz Ralf,Miller Ian S.,Loupakis Fotios,Lenz Heinz-Josef,Byrne Annette T.,Ebert Matthias P.

Funder

European Commission Seventh Framework Programme

Deutsche Krebshilfe

Studienstiftung des deutschen Volkes

Translational Physician Scientist (TraPS) Program of the Medical Faculty Mannheim of the Heidelberg University

Chinese Scholarship Council

State of Baden-Württemberg

European Commission Horizon 2020 Programme

Science Foundation Ireland

National Cancer Institute

Gloria Borges WunderGlo Foundation-The Wunder Project

Dhont Family Foundation

San Pedro Peninsula Cancer Guild

Daniel Butler Research Fund

Call to Cure Research Fund

Merck Serono and Roche

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference70 articles.

1. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer;Ferrara;Nat Rev Drug Discov,2004

2. Microenvironmental regulation of tumour angiogenesis;De Palma;Nat Rev Cancer,2017

3. A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells;Koyanagi;Cancer Res,2003

4. Circadian clock interaction with HIF1alpha mediates oxygenic metabolism and anaerobic glycolysis in skeletal muscle;Peek;Cell Metab,2017

5. Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1alpha-VEGF signaling pathway;Ma;Cell Cycle,2019

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