Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study

Author:

Kinnunen Kirsi M.1,Cash David M.12,Poole Teresa13,Frost Chris13,Benzinger Tammie L.S.14,Ahsan R. Laila1,Leung Kelvin K.1,Cardoso M. Jorge12,Modat Marc12,Malone Ian B.1,Morris John C.5,Bateman Randall J.5,Marcus Daniel S.14,Goate Alison6,Salloway Stephen P.7,Correia Stephen7,Sperling Reisa A.8,Chhatwal Jasmeer P.8,Mayeux Richard P.9,Brickman Adam M.9,Martins Ralph N.10,Farlow Martin R.11,Ghetti Bernardino12,Saykin Andrew J.13,Jack Clifford R.14,Schofield Peter R.1516,McDade Eric5,Weiner Michael W.17,Ringman John M.18,Thompson Paul M.19,Masters Colin L.20,Rowe Christopher C.2122,Rossor Martin N.1,Ourselin Sebastien12,Fox Nick C.1,

Affiliation:

1. Department of Neurodegenerative Disease, Dementia Research Centre UCL Institute of Neurology London UK

2. Department of Medical Physics and Bioengineering, Translational Imaging Group, Centre for Medical Image Computing University College London London UK

3. Department of Medical Statistics London School of Hygiene & Tropical Medicine London UK

4. Department of Radiology Washington University School of Medicine St. Louis MO USA

5. Department of Neurology Washington University School of Medicine St. Louis MO USA

6. Department of Neuroscience Icahn School of Medicine at Mount Sinai New York NY USA

7. Department of Neurology, Butler Hospital, Warren Alpert Medical School Brown University Providence RI USA

8. Department of Neurology, Massachusetts General Hospital Harvard Medical School Boston MA USA

9. Department of Neurology Columbia University Medical Center New York NY USA

10. Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences Edith Cowan University Joondalup WA Australia

11. Department of Neurology Indiana University School of Medicine Indianapolis IN USA

12. Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN USA

13. Department of Radiology and Imaging Sciences, Centre for Neuroimaging Indiana University School of Medicine Indianapolis IN USA

14. Department of Radiology Mayo Clinic Rochester MN USA

15. Neuroscience Research Australia Randwick NSW Australia

16. School of Medical Sciences University of New South Wales Sydney NSW Australia

17. Department of Radiology, School of Medicine University of California San Francisco San Francisco CA USA

18. Department of Neurology Keck USC School of Medicine Los Angeles CA USA

19. Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine University of Southern California Marina del Rey CA USA

20. The Florey Institute University of Melbourne Parkville VIC Australia

21. Department of Nuclear Medicine and Centre for PET Austin Health Heidelberg VIC Australia

22. Department of Medicine University of Melbourne, Austin Health Heidelberg VIC Australia

Funder

National Institute on Aging

National Institute for Health Research

Alzheimer's Society

Brain Research Trust

Wolfson Foundation

Alzheimer's Research Trust

National Institute on Handicapped Research

Economic and Social Research Council

University of Oxford

National Institutes of Health

Avid Radiopharmaceuticals

Roche

American Academy of Neurology

AstraZeneca

BrightFocus Foundation

Biogen Idec

Eisai

Eli Lilly and Company

Biogen

Genentech

Merck

American Health Assistance Foundation

U.S. Department of Defense

GE Healthcare

Engineering and Physical Sciences Research Council

Medical Research Council

Dominantly Inherited Alzheimer's Network

National Institute for Health Research (NIHR)

Queen Square Dementia Biomedical Research Unit, the Alzheimer's Society

Medical Research Council's (MRC) Dementias Platform UK (DPUK)

Department of Health's NIHR Biomedical Research Centre

UK Dementia Research Institute

Alzheimer's Research UK (ARUK)

The Wolfson Foundation

ARUK

Alzheimer's Research UK

Institute of Neurology, UCL

NIHR

National Institutes of Health (NIH)

Avid Radiopharmaceuticals (Eli Lilly)

NIH

DIAN

GENFI

DPUK

NIH/NIA

Alzheimer's Association

Anonymous Foundation

Cure Alzheimer's Fund

Glenn Foundation for Medical Research

Metropolitan Life Foundation

Elan Pharmaceuticals Inc.

Eli Lilly and Co.

Hoffman La-Roche Inc.

Genentech Inc.

Janssen Alzheimer Immunotherapy

Mithridion Inc.

Novartis Pharma AG

Pfizer Biotherapeutics R and D

Sanofi-Aventi

Ruth K. Broadman Biomedical Research Foundation

NIH/NINDS

Lilly

GE and Avid

Eli Lilly

Janssen

Bristol Myers Squibb

Mayo Foundation

NIA

Wicking and Mason Trusts

DOD

Veterans Administration

Alzheimer's Drug Discovery Foundation

Eli-Lilly

Piramal Imaging

EU-FP7

National Institute for Health Research University College London Hospitals Biomedical Research Centre

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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