Why has therapy development for dementia failed in the last two decades?-Reference-Cited by-同舟云学术

Why has therapy development for dementia failed in the last two decades?

Published:2015-12-19 Issue:1 Volume:12 Page:60-64
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Gauthier Serge¹,Albert Marilyn²,Fox Nick³,Goedert Michel⁴,Kivipelto Miia⁵,Mestre‐Ferrandiz Jorge⁶,Middleton Lefkos T.⁷

Affiliation:

1. Alzheimer's Disease Research Unit/Memory Clinic McGill Centre for Studies in Aging Montreal Quebec Canada

2. Division of Cognitive Neuroscience Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA

3. Dementia Research Centre Department of Neurodegenerative Disease UCL Institute of Neurology London UK

4. Division of Neurobiology MRC Laboratory of Molecular Biology Cambridge UK

5. Center for Alzheimer Research and Aging Research Center (ARC), Karolinska Institutet Department of Geriatric Medicine Clinical Trials Unit Karolinska University Hospital Huddinge Sweden

6. Office of Health Economics London UK

7. Neuroepidemiology and Ageing Research, School of Public Health Imperial College London London UK

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.jalz.2015.12.003

Reference13 articles.

1. MarsdenG Mestre‐FerrandizJ2015Dementia: The R&D landscape.OHE Research Report. Available at:https://worlddmentiacouncil.wordpress.com. Accessed October 22 2015.

2. G8 Dementia Summit Declaration. Available at:https://www.gov.uk/government/publications/g8‐dementia‐summit‐agreeements. Accessed April 29 2015.

3. Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

4. What does it take to produce a breakthrough drug?;Calcoen D;Nat Rev Drug Discov,2015

5. Health economic evaluation of treatments for Alzheimer′s disease: impact of new diagnostic criteria

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