A novel immunosuppressant, FTY720, induces peripheral lymphodepletion of both T- and B cells and immunosuppression in baboons

Author:

Quesniaux Valerie,Fullard Lynn,Arendse Hiram,Davison Glenda,Markgraaff Noel,Auer Roland,Ehrhart Francis,Kraus Gerolf,Schuurman Henk-Jan

Publisher

Elsevier BV

Subject

Transplantation,Immunology,Immunology and Allergy

Reference20 articles.

1. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propane-diols: discovery of a novel immunosuppressant, FTY 720;Adachi;Bioorg Med Chem Lett,1995

2. A novel immunosuppressant, FTY720, with a unique mechanisms of action, induces long-term graft acceptance in rat and dog allotransplantation;Suzuki;Transplantation,1996

3. Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats;Suzuki;Transplant Immunol,1996

4. FTY720, a novel immunosuppresant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats;Chiba;Transplant Proc,1996

5. FTY720, a novel immunosupressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing;Chiba;J Immunol,1998

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