Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases-Reference-Cited by-同舟云学术

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases

Published:2017-11-21 Issue:23 Volume:60 Page:9508-9530
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kurata Haruto¹^ORCID,Kusumi Kensuke¹,Otsuki Kazuhiro¹,Suzuki Ryo¹,Kurono Masakuni¹,Komiya Takaki,Hagiya Hiroshi,Mizuno Hirotaka,Shioya Hiroki,Ono Takeji,Takada Yuka,Maeda Tatsuo,Matsunaga Norikazu,Kondo Tetsu,Tominaga Sachiko,Nunoya Ken-ici,Kiyoshi Hidekazu²,Komeno Masaharu²,Nakade Shinji,Habashita Hiromu¹

Affiliation:

1. Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan

2. Safety Research Laboratories, Ono Pharmaceutical Co., Ltd., 50-10 Yamagishi, Mikuni, Sakai, Fukui 913-8538, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00785

Reference58 articles.

1. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

2. Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate