Synthesis of 21,21-Difluoro-3β-hydroxy-20-methylpregna-5,20-diene and 5,16,20-Triene as potential inhibitors of steroid C17(20) lyase-Reference-Cited by-同舟云学术

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Synthesis of 21,21-Difluoro-3β-hydroxy-20-methylpregna-5,20-diene and 5,16,20-Triene as potential inhibitors of steroid C17(20) lyase

Published:2003-02 Issue:3 Volume:11 Page:427-431
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Weintraub Philip M,Holland Amy K,Gates Cynthia A,Moore William R,Resvick Robert J,Bey Philippe,Peet Norton P

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. P450-dependent enzymes as targets for prostate cancer therapy

2. Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.

3. Characterization of Complementary Deoxyribonucleic Acid for Human Adrenocortical 17α-Hydroxylase: A Probe for Analysis of 17α-Hydroxylase Deficiency*

4. 17β-(Cyclopropylamino)-androst-5-en-3β-ol, a selective mechanism-based inhibitor of cytochrome P45017α (steroid 17α-hydroxylase/C17–20 lyase)

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