Abstract
Abstract
N-(Difluoropropenyl)amides/amines are an important class of fluorinated compounds. Here, we report an efficient method for synthesizing these compounds without the use of transition metals. Under simple base-promoted conditions, 3-bromo-3,3-difluoroprop-1-ene reacts with N-methylanilines or N-arylacrylamides, with the elimination of one molecule of HBr, to give the target compound. Another efficient method for synthesizing difluoroalkenes is the reaction of 2-bromo-3,3,3-trifluoroprop-1-ene with indole or its analogues.
Funder
National Natural Science Foundation of China
Key Research and Development Project of Shaanxi Province
Basic Research Project of Natural Science of Shaanxi Province
Shaanxi Provincial Department of Education Science and Technology Project