A new assay for functional screening of BRCA2 linker region mutations identifies variants that alter chemoresistance to cisplatin

Author:

Warren Curtis R.,Catts Zohra Ali-Khan,Farach-Carson Mary C.

Funder

Center for Translational Cancer Research

PO1 NIH/NCI P01

Cancer Genetics Fund from the Helen F. Graham Cancer Center (Christiana Care Health Systems, Newark DE)

Publisher

Elsevier BV

Subject

Cell Biology

Reference28 articles.

1. Understanding germ-line mutations in BRCA1;Szabo;Cancer Biol. Ther.,2004

2. Breast Cancer Information Core, National Institutes of Health—National Human Genome Research Institute;Brody,2007

3. Functional assays for BRCA1 and BRCA2;Carvalho;Int. J. Biochem. Cell Biol.,2007

4. Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2;Kuznetsov;Nat. Med.,2008

5. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein;Davies;Mol. Cell,2001

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