Direct evidence from siRNA-directed “knock down” that p16INK4a is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation

Author:

Bond Jane,Jones Christopher,Haughton Michele,DeMicco Catherine,Kipling David,Wynford-Thomas David

Publisher

Elsevier BV

Subject

Cell Biology

Reference23 articles.

1. Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms;Wynford-Thomas;Horm. Res.,1997

2. In vitro models of thyroid cancer;Wynford-Thomas;Cancer Surv.,1993

3. In vitro reconstruction of tumour initiation in a human epithelium;Bond;Oncogene,1994

4. High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis;Lemoine;Oncogene,1989

5. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a;Serrano;Cell,1997

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