p16INK4a-siRNA nanoparticles attenuate cartilage degeneration in osteoarthritis by inhibiting inflammation in fibroblast-like synoviocytes-Reference-Cited by-同舟云学术

p16INK4a-siRNA nanoparticles attenuate cartilage degeneration in osteoarthritis by inhibiting inflammation in fibroblast-like synoviocytes

Published:2022 Issue:12 Volume:10 Page:3223-3235
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Park Hyewon¹²^ORCID,Lee Ha-Reum³,Shin Hyo Jung²,Park Ji Ah⁴,Joo Yongbum⁵,Kim Sun Moon⁶,Beom Jaewon⁷,Kang Seong Wook⁸,Kim Dong Woon¹²^ORCID,Kim Jinhyun⁸^ORCID

Affiliation:

1. Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea

2. Department of Anatomy & Cell Biology, Brain Research Institute, Chungnam National University College of Medicine, Daejeon, Republic of Korea

3. Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon, Republic of Korea

4. Brain Research Institute, Chungnam National University College of Medicine, Daejeon, Republic of Korea

5. Department of Orthopedics, Chungnam National University College of Medicine, Daejeon, Republic of Korea

6. Department of Internal Medicine, Chungbuk National University Hospital, Cheong-ju, Chungcheongbuk-do, Republic of Korea

7. Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Republic of Korea

8. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea

Abstract

PLGA nanoparticle encapsulating p16INK4a siRNA can attenuate osteoarthritis by targeting fibroblast-like synoviocyte.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D1BM01941D

Reference49 articles.