1. A knockout mouse is a genetically engineered mouse where an existing gene has been replaced with an artificial piece of DNA. The loss of gene activity often changes the mouse's phenotype and as a consequence serves as an important animal model to study the role of genes in disease.
2. Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists
3. Discovery of Innovative Small Molecule Therapeutics
4. Impact of high-throughput screening in biomedical research