Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis

Author:

Thuita J.K.,Karanja S.M.,Wenzler T.,Mdachi R.E.,Ngotho J.M.,Kagira J.M.,Tidwell R.,Brun R.

Publisher

Elsevier BV

Subject

Infectious Diseases,Parasitology,Insect Science,Veterinary (miscalleneous)

Reference13 articles.

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2. Present status of chemotherapy and chemoprophylaxis of human trypanosomiais in the Eastern hemisphere;Apted;Pharmacol. Therapeutics,1980

3. Differential susceptibility to DL-α-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense;Bacchi;Antimicrob. Agents Chemother.,1990

4. In vivo efficacies of of 5′-methylthioadenosine analogs as trypanocides;Bacchi;Antimicrob. Agents Chemother.,1997

5. Bernhard, S.C., 2006. Treatment of African trypanosomosis with DB75: pharmacokinetics, relapses and cross resistance. Ph.D. thesis, University of Basel, Switzerland.

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