Partial Agonists Activate PPARγ Using a Helix 12 Independent Mechanism-Reference-Cited by-同舟云学术

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Partial Agonists Activate PPARγ Using a Helix 12 Independent Mechanism

Published:2007-10 Issue:10 Volume:15 Page:1258-1271
ISSN:0969-2126
Container-title:Structure
language:en
Short-container-title:Structure

Author:

Bruning John B.,Chalmers Michael J.,Prasad Swati,Busby Scott A.,Kamenecka Theodore M.,He Yuanjun,Nettles Kendall W.,Griffin Patrick R.

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference48 articles.

1. Benzoyl 2-methyl indoles as selective PPARgamma modulators;Acton;Bioorg. Med. Chem. Lett.,2005

2. IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1;Bendixen;Proc. Natl. Acad. Sci. USA,2001

3. Physiological and therapeutic roles of peroxisome proliferator-activated receptors;Berger;Diabetes Technol. Ther.,2002

4. Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator;Berger;Mol. Endocrinol.,2003

5. PPARs: therapeutic targets for metabolic disease;Berger;Trends Pharmacol. Sci.,2005

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1. Structure-based screening, optimization and biological evaluation of novel chrysin-based derivatives as selective PPARγ modulators for the treatment of T2DM and hepatic steatosis;European Journal of Medicinal Chemistry;2024-10

2. Exploring fingerprints for antidiabetic therapeutics related to peroxisome proliferator-activated receptor gamma (PPARγ) modulators: A chemometric modeling approach;Computational Biology and Chemistry;2024-10

3. A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties;European Journal of Medicinal Chemistry;2024-09

4. Cladosporols and PPARγ: Same Gun, Same Bullet, More Targets;Biomolecules;2024-08-13

5. Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ;2024-07-18

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