The in vitro and in vivo reaction at the N7-position of guanine of the ultimate carcinogen derived from benzo[a]pyrene

Author:

King H.W.S.,Osborne M.R.,Brookes P.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference15 articles.

1. Metabolic activation of benzo(a)pyrene proceeds by a diol epoxide;Sims;Nature (Lond.),1974

2. (±)-7α,8β-dihydro-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an intermediate in the metabolism and binding to DNA benzo(a)pyrene;King,1976

3. Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7, t-8-dihydroxy-t,9,10-oxy-7, 8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7,t-8-dihydiroxy-7, 8-dihydrobenzo(a)pyrene;Yang,1976

4. The reaction of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA involves attack at the N7-positi guanine moieties;Osborne;Chem.-Biol. Interact.,1978

5. The reaction of (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA;Osborne;Int. J. Cancer,1976

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