Emerging Three-Dimensional Hepatic Models in Relation to Traditional Two-Dimensional In Vitro Assays for Evaluating Drug Metabolism and Hepatoxicity

Author:

Milner Erin,Ainsworth Michael,McDonough Matthew,Stevens Benjamin,Buehrer Johannah,Delzell Richard,Wilson Cameron,Barnhill Jason

Funder

United States Military Academy

Publisher

Elsevier BV

Subject

Pharmacology (medical),Drug Discovery,Pharmacology

Reference69 articles.

1. Drug-Induced Liver Injury: Premarketing Clinical Evaluation;U.S. Department of Health and Human Services,2009

2. Hepatic and Intestinal Drug Transporters: Prediction of Pharmacokinetics Effects Caused by Drug-Drug Interactions and Genetic Polymorphisms;Yoshida;Annu Rev Pharmacol Toxicol,2013

3. Safety Testing of Drug Metabolites: Guidance for Industry;U.S. Department of Health and Human Services,2020

4. Characterization of hepatocyte-based in vitro systems for reliable toxicity testing;Vinken;Arch Toxicol,2018

5. Competency of different cell models to predict human heparotoxic drugs;Gómez-Lechón;Expert Opin Drug Metab Toxicol,2014

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