Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation

Author:

Yamaji Kazuyo,Wang Yin,Liu Yan,Abeyama Kazuhiro,Hashiguchi Teruto,Uchimura Tomonori,Krishna Biswas Kamal,Iwamoto Hisahiko,Maruyama Ikuro

Publisher

Elsevier BV

Subject

Hematology

Reference31 articles.

1. Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production;Murakami;Am. J. Physiol.,1997

2. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester;Grey;J. Immunol.,1994

3. Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line;White;Br. J. Haematol.,2000

4. Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis;Joyce;J. Biol. Chem.,2001

5. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins;Yan;J. Biol. Chem.,1994

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