The factor VIII heavy chain improves emicizumab-tenase assembly to enhance the factor VIII-mimicking cofactor activity
Author:
Funder
Ministry of Education, Culture, Sports, Science and Technology
Publisher
Elsevier BV
Subject
Hematology
Reference10 articles.
1. Activation of factor VIII and mechanisms of cofactor action;Fay;Blood Rev.,2004
2. Factor VIII structure and function;Fay;Int. J. Hematol.,2006
3. A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model;Kitazawa;Nat. Med.,2012
4. Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens;Kitazawa;Thromb. Haemost.,2017
5. Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity;Sampei;PLoS One,2013
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