3-Acetyl-5-acylpyridin-2(1H)-ones and 3-acetyl-7,8-dihydro-2,5(1H,6H)-quinolinediones: synthesis, cardiotonic activity and computational studies

Author:

Lo Presti Eleonora,Boggia Raffaella,Feltrin Antonio,Menozzi Giulia,Dorigo Paola,Mosti Luisa

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmaceutical Science

Reference21 articles.

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2. Amrinone: a positive inotropic agent with a direct vasodilatatory activity in the canine isolated perfused hind limb preparation;Alousi;Fed. Proc.,1980

3. Reaction of 2-dimethylamino-methylene-1,3-diones with dinucleophiles. V. Synthesis of 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles and 1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarboxamides;Mosti;J. Heterocycl. Chem.,1985

4. A pharmacological, crystallographic and quantum chemical study of new inotropic agents;Dorigo;J. Med. Chem.,1993

5. 2-Pyridone derivatives as inotropic agents: synthesis, pharmacology and molecular modeling study;Mosti;Farmaco,1997

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