Microwave‐assisted synthesis of benzo[4,5]imidazo[1,2‐a]pyrimidines and pyrano[4,3‐b]pyrans catalyzed by L‐glutamine functionalized magnetic nanoparticles in water:ethanol mixture

Author:

Thongni Aiborlang1,Nongkhlaw Rishanlang1ORCID,Pandya Chayan2,Sivaramakrishna Akella2,Gannon Paige M.3,Kaminsky Werner3

Affiliation:

1. Centre for Advanced Studies in Chemistry North Eastern Hill University Shillong India

2. Department of Chemistry Vellore Institute of Technology (VIT) Vellore India

3. Department of Chemistry University of Washington Seattle Washington USA

Abstract

AbstractIn this work, we report an effective, one‐pot syntheses of benzo[4,5]imidazo[1,2‐a]pyrimidine and pyrano[4,3‐b]pyran derivatives using L‐glutamine functionalized nanoparticles (Fe3O4@SiO2@L‐glutamine NPs) under microwave irradiation. The organo‐nanocatalyst underwent characterization through diverse techniques, including FT‐IR, p‐XRD, SEM, TEM, EDX, XPS, TGA, and VSM. Microwave irradiation and multicomponent reactions synergistically yield excellent product yields (≈80%–95%) in shorter reaction times (≈6–15 min) with a broader substrate scope. The organo‐nanocatalyst displays notable catalytic efficacy, evidenced by high turnover numbers (TON) and turnover frequencies (TOF) across syntheses. This innovative protocol showcases exceptional efficiency, cost‐effectiveness, and environmental friendliness, with advantages like minimal reaction conditions, easy catalytic recovery, recyclability, operational simplicity, and the use of eco‐friendly solvents.

Publisher

Wiley

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