Synthesis and biological evaluation of new amino acids structurally related to the antitumor agent acivicin

Author:

Conti Paola,Roda Gabriella,Stabile Helena,Vanoni Maria Antonietta,Curti Bruno,De Amici Marco

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmaceutical Science

Reference23 articles.

1. A new antitumor antimetabolite, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): antimicrobial reversal studies and preliminary evaluation against L1210 mouse leukemia in vivo;Hanka;Cancer Chemother. Rep.,1973

2. l-[αS,5S]-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): a new amino acid antibiotic with the properties of an antagonist of l-glutamine;Jayaram;Cancer Chemother. Rep.,1975

3. Acivicin in 1985;Earhart;Adv. Enzyme Regul.,1985

4. Mechanism of inactivation of glutamine amidotransferases by the antitumor drug l-(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125);Tso;J. Biol. Chem.,1980

5. The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501);Allen;Res. Commun. Chem. Pathol. Pharmacol.,1980

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