Affiliation:
1. Department of Chemistry, Nizam College, Osmania University, Hyderabad-500001, India
Abstract
The synthesis of new isoxazoline/isoxazole pyrano fused flavone derivatives from 6-hydroxy 5-formyl
flavone via in situ generation of nitrile oxide from aldoxime using ceric ammonium nitrate (CAN) as
an oxidant followed by intramolecular cycloaddition reaction at olefin/alkyne functions is reported in
high yields. The reaction involves regio selective annulation at C5/C6 position in preference to the
C6/C7 position of flavones. All the synthesized compounds were successfully characterized by IR, 1H
NMR, 13C NMR and ESI-MS.
Publisher
Asian Journal of Chemistry