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Antisense oligonucleotide therapies for Amyotrophic Lateral Sclerosis: Existing and emerging targets

  • Published:2019-05 Issue: Volume:110 Page:149-153
  • ISSN:1357-2725
  • Container-title:The International Journal of Biochemistry & Cell Biology
  • language:en
  • Short-container-title:The International Journal of Biochemistry & Cell Biology

Author:

Klim Joseph R.,Vance Caroline,Scotter Emma L.ORCID

Funder

the Project ALS Tom Kirchhoff Family Postdoctoral Fellowship

Motor Neuron Disease Association UK

NIHR Biomedical Research Centre for Mental Health

The Psychiatry Research Trust of the Institute of Psychiatry Psychology and Neuroscience

Marsden FastStart

Rutherford Discovery Fellowship funding

Royal Society of New Zealand

Motor Neuron Disease NZ

PaR NZ Golfing Holidays

Sir Thomas and Lady Duncan Trust

The Coker Family Trust

Publisher

Elsevier BV

Subject

Cell Biology,Biochemistry

Reference30 articles.

1. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo;Apicco;Nat. Neurosci.,2018

2. Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides;Bailey;Nucleic Acids Res.,2017

3. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice;Becker;Nature,2017

4. Presentation at 28th International Symposium on ALS/MND: Preclinical Data for WVE-3972-01 Supporting ALS and FTD Programs;Brown,2017

5. From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models;Colombrita;Biochim. Biophys. Acta,2015

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