Activation of PPARγ intensified the effects of arsenic trioxide in acute promyelocytic leukemia through the suppression of PI3K/Akt pathway: Proposing a novel anticancer effect for pioglitazone

Author:

Esmaeili Shadi,Safaroghli-azar Ava,Pourbagheri-Sigaroodi Atieh,Salari Sina,Gharehbaghian Ahmad,hamidpour MohsenORCID,Bashash DavoodORCID

Funder

Iran National Science Foundation

Shahid Beheshti University of Medical Sciences

Publisher

Elsevier BV

Subject

Cell Biology,Biochemistry

Reference34 articles.

1. The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell differentiation and cell death;Ahuja;J. Biol. Regul. Homeost. Agents,2003

2. Treatment of relapsed acute promyelocytic leukemia by arsenic trioxide in Iran;Alimoghaddam;Arch. Iran. Med.,2011

3. Inhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO);Alipour;Int. J. Biochem. Cell Biol.,2019

4. Targeting human telomerase RNA component using antisense oligonucleotide induces rapid cell death and increases ATO-induced apoptosis in APL cells;Asghari-Kia;Eur. J. Pharmacol.,2017

5. Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt;Bai;Int. J. Cancer,2009

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