Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): Optimization for JNK potency and physicochemical properties-Reference-Cited by-同舟云学术

Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): Optimization for JNK potency and physicochemical properties

Published:2013-06 Issue:12 Volume:23 Page:3565-3569
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Gong Leyi,Han Xiaochun,Silva Tania,Tan Yun-Chou,Goyal Bindu,Tivitmahaisoon Parch,Trejo Alejandra,Palmer Wylie,Hogg Heather,Jahagir Alam,Alam Muzaffar,Wagner Paul,Stein Karin,Filonova Lubov,Loe Brad,Makra Ferenc,Rotstein David,Rapatova Lubica,Dunn James,Zuo Fengrong,Porto Joseph Dal,Wong Brian,Jin Sue,Chang Alice,Tran Patricia,Hsieh Gary,Niu Linghao,Shao Ada,Reuter Deborah,Hermann Johaness,Kuglstatter Andreas,Goldstein David

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference23 articles.

1. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

2. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

3. Selective interaction of JNK protein kinase isoforms with transcription factors.

4. Developmental expression in the mouse nervous system of the p493F12 SAP kinase

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