Discovery of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one and 3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one derivatives as novel ENPP1 inhibitors-Reference-Cited by-同舟云学术

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Discovery of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one and 3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one derivatives as novel ENPP1 inhibitors

Published:2022-11 Issue: Volume:75 Page:128947
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Jung Jae Eun,Jang Yunseong,Jeong Hee Jin,Kim Sung Joon,Park Kichul,Oh Do Hee,Yu Ahran,Park Chan Sun,Han Seo-Jung

Funder

National Research Council of Science and Technology

Ministry of Science, ICT and Future Planning

Ministry of SMEs and Startups

Ministry of Health and Welfare

Korea Institute of Science and Technology

National Research Foundation of Korea

Korea Drug Development Fund

Ministry of Trade, Industry and Energy

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. Immune checkpoint blockade across the cancer care continuum;Helmink;Immunity,2018

2. The future of immune checkpoint therapy;Sharma;Science,2015

3. A decade of immune-checkpoint inhibitors in cancer therapy;Robert;Nat Commun,2020

4. Melanoma drugs wins US approval;Ledford;Nature,2011

5. Fundamental mechanisms of immune checkpoint blockade therapy;Wei;Cancer Discov,2018

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2. Insight into small-molecule inhibitors targeting extracellular nucleotide pyrophosphatase/phosphodiesterase1 for potential multiple human diseases;European Journal of Medicinal Chemistry;2024-03

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4. Naturally occurring quercetin and myricetin as potent inhibitors for human ectonucleotide pyrophosphatase/phosphodiesterase 1;Scientific Reports;2024-01-02

5. Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy;Journal of Medicinal Chemistry;2023-11-14

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