Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy-Reference-Cited by-同舟云学术

Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy

Published:2023-11-14 Issue:22 Volume:66 Page:15141-15170
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cho Yeonguk¹^ORCID,Kang Miso²³,Ji Su Hyun⁴⁵,Jeong Hee Jin⁴,Jung Jae Eun⁴,Oh Do Hee⁴,Park Sunyoung⁶,Park Yong-Yea⁶,Choi Junghwan⁶,Kim Sungjoon⁶,Kim Nam-Jung²^ORCID,Lee Duck-Hyung⁵,Park Chan Sun⁶,Han Seo-Jung⁴⁷^ORCID,Lee Sanghee³⁸^ORCID,Choi Junwon¹^ORCID

Affiliation:

1. Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea

2. Department of Fundamental Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

3. Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea

4. Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea

5. Department of Chemistry, Sogang University, Seoul 04107, Republic of Korea

6. Txinno Bioscience Inc., Yongin 16942, Republic of Korea

7. Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea

8. Department for HY-KIST Bio-convergence, Hanyang University, Seoul 04763, Republic of Korea

Funder

Korea Drug Development Fund

Korea Health Industry Development Institute

Ministry of Science and ICT, South Korea

Korea Institute of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01061

Reference40 articles.

1. Turning cold tumors into hot tumors by improving T-cell infiltration

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5. Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

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