Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles-Reference-Cited by-同舟云学术

Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles

Published:2008-03 Issue:6 Volume:18 Page:2062-2066
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Isaacs Richard C.A.,Solinsky Mark G.,Cutrona Kellie J.,Newton Christina L.,Naylor-Olsen Adel M.,McMasters Daniel R.,Krueger Julie A.,Lewis S. Dale,Lucas Bobby J.,Kuo Lawrence C.,Yan Youwei,Lynch J.J.,Lyle E.A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles

2. Rat model of arterial thrombosis induced by ferric chloride

3. Inhibition of Thrombin by Peptides Containing Lysyl-α-Keto Carbonyl Derivatives

4. In a typical experiment, six rats are evaluated. Full efficacy is defined as when none of the animals occlude i.e., 0/6 occlusions.

5. L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor

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