L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor-Reference-Cited by-同舟云学术

L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor

Published:1998-04 Issue:7 Volume:8 Page:817-822
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Sanderson Philip E.J.,Cutrona Kellie J.,Dorsey Bruce D.,Dyer Dona L.,McDonough Colleen M.,Naylor-Olsen Adel M.,Chen I-Wu,Chen Zhongguo,Cook Jacquelynn J.,Gardell Stephen J.,Krueger Julie A.,Lewis S.Dale,Lin Jiunn H.,Lucas Bobby J.,Lyle Elizabeth A.,Lynch Joseph J.,Stranieri Maria T.,Vastag Kari,Shafer Jules A.,Vacca Joseph P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. Synthetic Low-Molecular Weight Thrombin Inhibitors: The Ideal Antithrombotic Drug? an Introduction

2. Challenges in the development of orally bioavailable thrombin active site inhibitors

3. Orally Effective CVS-1123 Prevents Coronary Artery Thrombosis in the Conscious Dog

4. CVS-1123, A Direct Thrombin Inhibitor, Prevents Occlusive Arterial and Venous Thrombosis in a Canine Model of Vascular Injury

5. Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates

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