1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia-Reference-Cited by-同舟云学术

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

Published:2011-02 Issue:3 Volume:21 Page:983-988
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Anandan Sampath-Kumar,Webb Heather Kay,Chen Dawn,Wang Yi-Xin (Jim),Aavula Basker R.,Cases Sylvaine,Cheng Ying,Do Zung N.,Mehra Upasana,Tran Vinh,Vincelette Jon,Waszczuk Joanna,White Kathy,Wong Kenneth R.,Zhang Le-Ning,Jones Paul D.,Hammock Bruce D.,Patel Dinesh V.,Whitcomb Randall,MacIntyre D. Euan,Sabry James,Gless Richard

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference61 articles.

1. Soluble Epoxide Hydrolase, a Target with Multiple Opportunities for Cardiovascular Drug Discovery

2. Soluble epoxide hydrolase inhibitors: a patent review

3. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase

4. 1-Aryl-3-(1-acylpiperidin-4-yl)urea Inhibitors of Human and Murine Soluble Epoxide Hydrolase: Structure−Activity Relationships, Pharmacokinetics, and Reduction of Inflammatory Pain

5. A randomized, double-blind, placebo-controlled, dose-ranging, exploratory, 28-day study to examine the effects of AR9281 on blood pressure and glucose tolerance in patients with mild to moderate hypertension and impaired glucose tolerance. ClinicalTrials.gov, ID NCT00847899.

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