1-Aryl-3-(1-acylpiperidin-4-yl)urea Inhibitors of Human and Murine Soluble Epoxide Hydrolase: Structure−Activity Relationships, Pharmacokinetics, and Reduction of Inflammatory Pain-Reference-Cited by-同舟云学术

1-Aryl-3-(1-acylpiperidin-4-yl)urea Inhibitors of Human and Murine Soluble Epoxide Hydrolase: Structure−Activity Relationships, Pharmacokinetics, and Reduction of Inflammatory Pain

Published:2010-09-02 Issue:19 Volume:53 Page:7067-7075
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rose Tristan E.¹,Morisseau Christophe¹,Liu Jun-Yan¹,Inceoglu Bora¹,Jones Paul D.¹,Sanborn James R.¹,Hammock Bruce D.¹

Affiliation:

1. Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, California 95616

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100691c

Reference49 articles.

1. Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

2. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

3. Soluble epoxide hydrolase is a therapeutic target for acute inflammation

4. Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids

5. Soluble epoxide hydrolase inhibition: targeting multiple mechanisms of ischemic brain injury with a single agent

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