Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists-Reference-Cited by-同舟云学术

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Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists

Published:2017-04 Issue:8 Volume:27 Page:1760-1764
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Zhang Xuqing,Sui Zhihua,Kauffman Jack,Hou Cuifen,Chen Cailin,Du Fuyong,Kirchner Thomas,Liang Yin,Johnson Dana,Murray William V.,Demarest Keith

Funder

Janssen R&D

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders

2. Identification of membrane-type receptor for bile acids (M-BAR)

3. A G Protein-coupled Receptor Responsive to Bile Acids

4. Targeting bile-acid signalling for metabolic diseases

5. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

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1. Imidazole‐Oxadiazole Hybrid as Potential Antimicrobial Agents: Design, Synthesis, Drug–Likeness, Pharmacophore and Molecular Docking Study;ChemistrySelect;2024-08-22

2. Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties;Bioorganic Chemistry;2024-03

3. Structural dynamics and anti-biofilm screening of novel imidazole derivative to explore their anti-biofilm inhibition mechanism against Pseudomonas Aeruginosa;Journal of Biomolecular Structure and Dynamics;2024-02-22

4. Discovery, Structure–Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5;Journal of Medicinal Chemistry;2023-08-28

5. Synthesis, Biological Evaluation, Molecular Docking and Kinetic Investigation of New 2,4,5‐Trisubstituted Imidazole Derivatives as Antidiabetic Agents;ChemistrySelect;2023-08-16

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