Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties-Reference-Cited by-同舟云学术

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Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties

Published:2014-11 Issue:21 Volume:24 Page:5098-5101
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Xia Guoyao,Benmohamed Radhia,Morimoto Richard I.,Kirsch Donald R.,Silverman Richard B.

Funder

National Institutes of Health

ALS Association

Department of Defense

ALS Therapy Alliance

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. Harrison’s Principles of Internal Medicine;Brown,1998

2. Riluzole Series. Synthesis and in Vivo “Antiglutamate” Activity of 6-Substituted-2-benzothiazolamines and 3-Substituted-2-imino-benzothiazolines

3. A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis

4. Evaluation and rehabilitation of patients with adult motor neuron disease

5. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

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