Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain-Reference-Cited by-同舟云学术

Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain

Published:2013-09 Issue:17 Volume:23 Page:4857-4861
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Beebe Xenia,Yeung Clinton M.,Darczak Daria,Shekhar Shashank,Vortherms Timothy A.,Miller Loan,Milicic Ivan,Swensen Andrew M.,Zhu Chang Z.,Banfor Patricia,Wetter Jill M.,Marsh Kennan C.,Jarvis Michael F.,Scott Victoria E.,Schrimpf Michael R.,Lee Chih-Hung

Funder

AbbVie HT-ADME group

AbbVie structural chemistry group

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. Presynaptic Calcium Channels: Structure, Regulators, and Blockers

2. Ziconotide for treatment of severe chronic pain

3. Asymmetric synthesis and biological evaluations of (+)- and (−)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels

4. A potent and selective indole N-type calcium channel (Cav2.2) blocker for the treatment of pain

5. A novel series of pyrazolylpiperidine N-type calcium channel blockers

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