Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels-Reference-Cited by-同舟云学术

Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels

Published:2014-12 Issue:24 Volume:22 Page:6899-6907
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Ogiyama Takashi,Inoue Makoto,Honda Shugo,Yamada Hiroyoshi,Watanabe Toshihiro,Gotoh Takayasu,Kiso Tetsuo,Koakutsu Akiko,Kakimoto Shuichiro,Shishikura Jun-ichi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

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1. hERG toxicity assessment: Useful guidelines for drug design;European Journal of Medicinal Chemistry;2020-06

2. Tetrahydroisoquinolines;Privileged Structures in Drug Discovery;2018-03-09

3. Corrigendum to “Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels” [Bioorg. Med. Chem. 22 (2014) 6899–6907];Bioorganic & Medicinal Chemistry;2015-09

4. Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability;Bioorganic & Medicinal Chemistry;2015-08

5. Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain;Bioorganic & Medicinal Chemistry;2015-08