Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead-Reference-Cited by-同舟云学术

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Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead

Published:2013-09 Issue:18 Volume:23 Page:5223-5227
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Cheng Yung-Yi,Liu Chin-Yu,Tsai Meng-Tung,Lin Hui-Yi,Yang Jai-Sing,Wu Tian-Shung,Kuo Sheng-Chu,Huang Li-Jiau,Lee Kuo-Hsiung

Funder

National Science Council of the Republic of China

National Cancer Institute

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin

2. Antitumor Agents. 150. 2',3',4',5',5,6,7-Substituted 2-Phenyl-4-quinolones and Related Compounds: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization

3. Antitumor Agents 155. Synthesis and Biological Evaluation of 3',6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents

4. Antitumor Agents. 199. Three-Dimensional Quantitative Structure−Activity Relationship Study of the Colchicine Binding Site Ligands Using Comparative Molecular Field Analysis

5. Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents

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2. Recent insight into the biological activities and SAR of quinolone derivatives as multifunctional scaffold;Bioorganic & Medicinal Chemistry;2022-04

3. Exploring Quinolone Scaffold: Unravelling the Chemistry of Anticancer Drug Design;Mini-Reviews in Medicinal Chemistry;2022-01

4. New Quinoline-2-one/thiazolium bromide Derivatives; Synthesis, Characterization and Mechanism of Formation;Journal of Molecular Structure;2021-09

5. Recent advances in the synthetic and medicinal perspective of quinolones: A review;Bioorganic Chemistry;2019-11

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