Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents-Reference-Cited by-同舟云学术

Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents

Published:2010-10-25 Issue:22 Volume:53 Page:8047-8058
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chou Li-Chen¹,Tsai Meng-Tung¹,Hsu Mei-Hua¹,Wang Sheng-Hung²,Way Tzong-Der³,Huang Chi-Hung⁴,Lin Hui-Yi¹,Qian Keduo⁵,Dong Yizhou⁵,Lee Kuo-Hsiung⁵,Huang Li-Jiau¹,Kuo Sheng-Chu¹

Affiliation:

1. Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan

2. Institute of Cellular and Organismic Biology, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan

3. School of Biological Science and Technology, China Medical University, Taichung, Taiwan

4. Taiwan Advance Biopharm, Inc., 12F, No. 25, Lane 169, Kangning Street, Xizhi City, Taipei 221, Taiwan

5. Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100780c

Reference26 articles.

1. Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin

2. Antitumor Agents. 150. 2',3',4',5',5,6,7-Substituted 2-Phenyl-4-quinolones and Related Compounds: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization

3. Antitumor Agents 155. Synthesis and Biological Evaluation of 3',6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents

4. Synthesis and Preclinical Evaluations of 2-(2-Fluorophenyl)-6,7-methylenedioxyquinolin-4-one Monosodium Phosphate (CHM-1−P-Na) as a Potent Antitumor Agent

5. Kuo, S. C.; Teng, C. M.; Lee, K. H.; Huang, L. J.; Chou, L. C.; Chang, C. S.; Sun, C. M.; Wu, T. S.; Pan, S. L.; Way, T. D.; Lee, J. C.; Chung, J. G.; Yang, J. S.; Chen, C. T.; Huang, C. C.; Huang, S. M.Novel Hydrophilic Derivatives of 2-Aryl-4-quinolones as Anticancer Agents. WO 2008/070176 A1 (PCT), 2008. [Patent Applied in Taiwan (96146890), U.S. (12/448088), Australia (2007328034), Canada (2670292), China (200780044796.9), EU (07853279.3), India (3052/EHENP/2009), Japan (2009-540310), Korea (10-2009-7014196), New Zealand (577130), Russian Fedeation (2009124622), South Africa (2009/03694).]

Cited by 63 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bioisosteric heterocyclic analogues of natural bioactive flavonoids by scaffold-hopping approaches: State-of-the-art and perspectives in medicinal chemistry;Bioorganic & Medicinal Chemistry;2024-07

2. CVM-1118 (foslinanib), a 2-phenyl-4-quinolone derivative, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1;Pathology and Oncology Research;2023-06-07

3. Spectral studies and nonlinear optical properties of an organic crystal: Piperazine-1, 4-diiumbis (4-aminobenzenesulfonate);Journal of Nonlinear Optical Physics & Materials;2023-05-13

4. Copper(ii) complex enhanced chemodynamic therapy through GSH depletion and autophagy flow blockade;Dalton Transactions;2023

5. Microwave‐Assisted Copper‐Catalyzed One‐Pot Synthesis of 2‐Aryl/Heteroaryl‐4‐Quinolones via Sequential Intramolecular Aza‐Michael Addition and Oxidation;Asian Journal of Organic Chemistry;2022-06-14