Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies-Reference-Cited by-同舟云学术

Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies

Published:2015-10 Issue:20 Volume:25 Page:4412-4418
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Devasthale Pratik,Wang Wei,Mignone James,Renduchintala Kishore,Radhakrishnan Sridhar,Dhanapal Jayanthi,Selvaraj Jagannath,Kuppusamy Rajesh,Pelleymounter Mary Ann,Longhi Daniel,Huang Ning,Flynn Neil,Azzara Anthony V.,Rohrbach Kenneth,Devenny James,Rooney Suzanne,Thomas Michael,Glick Susan,Godonis Helen,Harvey Susan,Cullen Mary Jane,Zhang Hongwei,Caporuscio Christian,Stetsko Paul,Grubb Mary,Huang Christine,Zhang Lisa,Freeden Chris,Murphy Brian J.,Robl Jeffrey A.,Washburn William N.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference14 articles.

1. Novel MCH1receptor antagonists: a patent review

2. Melanin concentrating hormone receptor 1 (MCHR1) antagonists—Still a viable approach for obesity treatment?

3. MCH-R1 antagonists: what is keeping most research programs away from the clinic?

4. Identification of a Nonbasic Melanin Hormone Receptor 1 Antagonist as an Antiobesity Clinical Candidate

5. Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup

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