Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors-Reference-Cited by-同舟云学术

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Published:2013-05 Issue:9 Volume:23 Page:2743-2749
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Bowers Simeon,Truong Anh P.,Ye Michael,Aubele Danielle L.,Sealy Jennifer M.,Neitz R. Jeffrey,Hom Roy K.,Chan Wayman,Dappen Michael S.,Galemmo Robert A.,Konradi Andrei W.,Sham Hing L.,Zhu Yong L.,Beroza Paul,Tonn George,Zhang Heather,Hoffman Jennifer,Motter Ruth,Fauss Donald,Tanaka Pearl,Bova Michael P.,Ren Zhao,Tam Danny,Ruslim Lany,Baker Jeanne,Pandya Deepal,Diep Linnea,Fitzgerald Kent,Artis Dean R.,Anderson John P.,Bergeron Marcelle

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Parkinson's disease

2. Neuropathology of Lewy body disorders

3. Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease

4. Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

5. Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

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