Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease-Reference-Cited by-同舟云学术

Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease

Published:2022-10 Issue: Volume:172 Page:105833
ISSN:0969-9961
Container-title:Neurobiology of Disease
language:en
Short-container-title:Neurobiology of Disease

Author:

Martínez-Drudis Laura,Sheta Razan,Pellegrinato Rémi,Loukili Salma,Tremblay Cyntia,Calon Frédéric,Rivest Serge,Oueslati Abid

Publisher

Elsevier BV

Subject

Neurology

Reference102 articles.

1. Cognitive and neurobiologic markers of early Alzheimer disease;Albert;Proc. Natl. Acad. Sci. U. S. A.,1996

2. PAK inactivation impairs social recognition in 3xTg-AD mice without increasing brain deposition of tau and Abeta;Arsenault;J. Neurosci.,2013

3. Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice;Arsenault;Biol. Sex Differ.,2020

4. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements;Asuni;J. Neurosci.,2007

5. Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain;Aubele;ChemMedChem.,2013

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