Identification and design of a novel series of MGAT2 inhibitors-Reference-Cited by-同舟云学术

Identification and design of a novel series of MGAT2 inhibitors

Published:2013-05 Issue:9 Volume:23 Page:2721-2726
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Barlind Jonas G.,Buckett Linda K.,Crosby Sharon G.,Davidsson Öjvind,Emtenäs Hans,Ertan Anne,Jurva Ulrik,Lemurell Malin,Gutierrez Pablo Morentin,Nilsson Karolina,O’Mahony Gavin,Petersson Annika U.,Redzic Alma,Wågberg Fredrik,Yuan Zhong-Qing

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. MGAT2, a Monoacylglycerol Acyltransferase Expressed in the Small Intestine

2. Enzymes of Glycerolipid Synthesis in Eukaryotes

3. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding

4. Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain

5. Previously disclosed structurally distinct MGAT inhibitors. Patents: WO 2008038768 (A1), WO 2010095767 (A1), WO 2012091010 (A1) and WO 2012124744 (A1).

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