Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5-Reference-Cited by-同舟云学术

Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Published:2018-06 Issue:10 Volume:28 Page:1679-1685
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Felts Andrew S.,Rodriguez Alice L.,Morrison Ryan D.,Blobaum Anna L.,Byers Frank W.,Daniels J. Scott,Niswender Colleen M.,Conn P. Jeffrey,Lindsley Craig W.,Emmitte Kyle A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Metabotropic Glutamate Receptors in Central Nervous System Diseases

2. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

3. Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

4. mGlu5negative allosteric modulators: a patent review (2013 - 2016)

5. Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials

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