Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors-Reference-Cited by-同舟云学术

Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors

Published:2011-08 Issue:15 Volume:21 Page:4633-4637
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Dyckman Alaric J.,Li Tianle,Pitt Sidney,Zhang Rosemary,Shen Ding Ren,McIntyre Kim W.,Gillooly Kathleen M.,Shuster David J.,Doweyko Arthur M.,Sack John S.,Kish Kevin,Kiefer Susan E.,Newitt John A.,Zhang Hongjian,Marathe Punit H.,McKinnon Murray,Barrish Joel C.,Dodd John H.,Schieven Gary L.,Leftheris Katerina

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference33 articles.

1. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

2. 1 p38 MAP Kinase: Molecular Target for the Inhibition of Pro-inflammatory Cytokines

3. The p38α Kinase Plays a Central Role In Inflammation

4. p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis

5. Pathways of Inflammatory Activation in Alzheimers Disease: Potential Targets for Disease Modifying Drugs

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