Substituted N -aryl-6-pyrimidinones: A new class of potent, selective, and orally active p38 MAP kinase inhibitors-Reference-Cited by-同舟云学术

Substituted N -aryl-6-pyrimidinones: A new class of potent, selective, and orally active p38 MAP kinase inhibitors

Published:2011-07 Issue:13 Volume:21 Page:3856-3860
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Devadas Balekudru,Selness Shaun R.,Xing Li,Madsen Heather M.,Marrufo Laura D.,Shieh Huey,Messing Dean M.,Yang Jerry Z.,Morgan Heidi M.,Anderson Gary D.,Webb Elizabeth G.,Zhang Jian,Devraj Rajesh V.,Monahan Joseph B.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. The p38 MAP kinase pathway as a therapeutic target in inflammatory disease

2. The Discovery of Novel Chemotypes of p38 Kinase Inhibitors

3. 1 p38 MAP Kinase: Molecular Target for the Inhibition of Pro-inflammatory Cytokines

4. Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases

5. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

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