Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leads-Reference-Cited by-同舟云学术

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leads

Published:2008-07 Issue:14 Volume:18 Page:4154-4158
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Van der Veken Pieter,De Meester Ingrid,Dubois Véronique,Soroka Anna,Van Goethem Sebastiaan,Maes Marie-Berthe,Brandt Inger,Lambeir Anne-Marie,Chen Xin,Haemers Achiel,Scharpé Simon,Augustyns Koen

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. Dipeptidyl-Peptidase IV from Bench to Bedside: An Update on Structural Properties, Functions, and Clinical Aspects of the Enzyme DPP IV

2. Efficacy and Safety of Incretin Therapy in Type 2 Diabetes

3. The Dipeptidyl Peptidase-4 Inhibitor Vildagliptin Improves β-Cell Function and Insulin Sensitivity in Subjects With Impaired Fasting Glucose

4. 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

5. Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

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1. Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin;Journal of Medicinal Chemistry;2023-09-18

2. Development of pyrrolidine and isoindoline derivatives as new DPP8 inhibitors using a combination of 3D-QSAR technique, pharmacophore modeling, docking studies, and molecular dynamics simulations;Molecular Simulation;2022-09-20

3. New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors;Frontiers in Pharmacology;2022-09-12

4. Vildagliptin‐Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9‐Specific Lead;ChemMedChem;2022-06-27

5. Human proline specific peptidases: A comprehensive analysis;Biochimica et Biophysica Acta (BBA) - General Subjects;2020-09