Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies-Reference-Cited by-同舟云学术

Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies

Published:2021-04 Issue: Volume:37 Page:127833
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Kai Hiroyuki,Horiguchi Tohru,Kameyama Takayuki,Asahi Kentaro,Endoh Takeshi,Jikihara Sae,Hasegawa Tsuyoshi,Tanaka Satoru,Nozu Azusa,Takeyama Chie,Tomari Maki,Takahashi Fumiyo,Tamura Naomi,Yagi Shigenori,Itoh Tetsuji,Isou Yasuyoshi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization

2. P2X receptor antagonists for pain management: examination of binding and physicochemical properties

3. Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications

4. P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

5. Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening

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3. Druggable site near the upper vestibule determines the high affinity and P2X3 homotrimer selectivity of sivopixant/S‐600918 and its analogue DDTPA;British Journal of Pharmacology;2023-12-07

4. Potential applications of P2X3 receptor antagonists in the treatment of refractory cough;Respiratory Medicine;2023-10

5. Role of ATP in migraine mechanisms: focus on P2X3 receptors;The Journal of Headache and Pain;2023-01-03