Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening-Reference-Cited by-同舟云学术

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 1: Initial structure-activity relationship studies of a hit from a high throughput screening

Published:2018-07 Issue:13 Volume:28 Page:2338-2342
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Tobinaga Hiroyuki^ORCID,Kameyama Takayuki,Oohara Miho,Kobayashi Naotake,Ohdan Masahide,Ishizuka Natsuki,Kume Masaharu,Tomari Maki,Tanaka Yoshikazu,Takahashi Fumiyo,Kinoshita Haruki,Shimada Shinji,Shinohara Shunji,Kai Hiroyuki

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference14 articles.

1. Molecular Physiology of P2X Receptors

2. International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy

3. A P2X purinoceptor expressed by a subset of sensory neurons

4. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

5. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

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