Synthesis and biological evaluation of novel imidazol-1-ylacetic acid derivatives as non-brain penetrant bombesin receptor subtype-3 (BRS-3) agonists-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of novel imidazol-1-ylacetic acid derivatives as non-brain penetrant bombesin receptor subtype-3 (BRS-3) agonists

Published:2016-09 Issue:17 Volume:26 Page:4205-4210
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Kiyotsuka Yohei^ORCID,Shimada Kousei,Kobayashi Shozo,Suzuki Masanori,Akiu Mayuko,Asano Masayoshi,Sogawa Yoshitaka,Hara Takashi,Konishi Masahiro,Abe-Ohya Rie,Izumi Masanori,Nagai Yoko,Yoshida Kazuhiro,Abe Yasuyuki,Takamori Hideo,Takahashi Hisashi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Molecular Basis of the Pharmacological Difference between Rat and Human Bombesin Receptor Subtype-3 (BRS-3)

2. Bombesin Receptor Subtype-3 (BRS-3) Regulates Glucose-Stimulated Insulin Secretion in Pancreatic Islets across Multiple Species

3. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity

4. Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

5. Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cre Recombinase Driver Mice Reveal Lineage-Dependent and -Independent Expression of Brs3 in the Mouse Brain;eneuro;2021-07

2. Bombesin Receptor Subtype-3 in Human Diseases;Archives of Medical Research;2019-10

3. Development and Characterization of a Novel, High-Affinity, Specific, Radiolabeled Ligand for BRS-3 Receptors;Journal of Pharmacology and Experimental Therapeutics;2019-04-10

4. Activation of bombesin receptor Subtype-3 by [D-Tyr 6 ,β-Ala 11 ,Phe 13 ,Nle 14 ]bombesin 6-14 increased glucose uptake and lipogenesis in human and rat adipocytes;Molecular and Cellular Endocrinology;2018-10

5. Biaryls;Privileged Structures in Drug Discovery;2018-03-09