Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity
Author:
Affiliation:
1. Departments of Medicinal Chemistry
2. Drug Metabolism
3. Metabolic Diseases (Obesity)
4. Pharmacology
5. AMRI, 26 Corporate Circle, Albany, New York 12212, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml100196d
Reference14 articles.
1. International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States
2. Two distinct receptor subtypes for mammalian bombesin-like peptides
3. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells.
4. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity
5. The design of a new potent and selective ligand for the orphan bombesin receptor subtype 3 (BRS3)
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